MyBioSource.com's Claudin 2 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot. The Claudin 2 Antibody was generated using Claudin 2, and CLDN2 as the antigen and it reacts with Human, and Mouse.
Description
Description: Claudin 2 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Belongs to the claudin family. Can form homo-and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subunit Structure: Can form homo-and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).
Post-translational Modifications: The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking.
Similarity: Belongs to the claudin family